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The importin α proteins IMPA1, IMPA2, and IMPA4 play redundant roles in suppressing autoimmunity in Arabidopsis thaliana
https://u-shizuoka-ken.repo.nii.ac.jp/records/2000358
https://u-shizuoka-ken.repo.nii.ac.jp/records/20003581c10199c-71df-4438-bb88-6c0b11fa5d83
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
240918 IMPA_clean+.pdf
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2025-07-01 | |||||
| タイトル | ||||||
| タイトル | The importin α proteins IMPA1, IMPA2, and IMPA4 play redundant roles in suppressing autoimmunity in Arabidopsis thaliana | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Mori, Airi
× Mori, Airi× Nakagawa, Shitomi× Suzuki, Toshiyuki× Suzuki, Takamasa× Valérie, Gaudin× Matsuura, Takakazu× Ikeda, Yoko× Tamura, Kentaro |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | SUMMARY Proteins in the importin α (IMPA) family play pivotal roles inintracellular nucleocytoplasmic transport. Arabidopsis thalianapossesses nine IMPA members, with diverse tissue-specific expressionpatterns. Among these nine IMPAS, IMPA1, IMPA2, and IMPA4 clustertogether phylogenetically, suggesting potential functional redundancy. Toexplore this redundancy, we analyzed single and multiple T-DNA mutants forthese genes and discovered severe growth defects in the impa1impa2impa4tripleknockout mutant but not in the single or double mutants. Complementationwith IMPA1, IMPA2, or IMPA4 fused to green fluorescent protein (GFP)rescued the growth defectsobservedintheimpa1impa2impa4mutant, indicating the functional redundancy of these three IMPAs. The IMPA-GFPfusion proteins were localized in the nucleus andnuclearenvelope,suggestingtheirinvolvementinnucleocytoplasmictransport processes. Comparativetranscriptomics revealed that salicylic acid (SA)- responsive genes were significantly upregulated in the impa1 impa2 impa4 triple mutant. Consistentwith this observation, impa1 impa2 impa4 mutant plants accumulated SA andreactive oxygen speciestohighlevelscompared with wild-type plants. Wealso found enhanced resistance to the anthracnose pathogen Colletotrichum higginsianum in the impa1 impa2 impa4 mutants, suggesting thatdefenseresponseswereconstitutively activated in the impa1 impa2 impa4 mutant. Ourfindings shed light on the redundant roles of IMPA1, IMPA2, and IMPA4 insuppressing the autoimmune responses and suggest avenues of research to clarify their potentially unique roles. |
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| 言語 | en | |||||
| bibliographic_information |
en : The Plant Journal 巻 121, 号 2, p. e17203-e17203, 発行日 2024-12-10 |
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| 出版者 | ||||||
| 出版者 | Wiley | |||||
| 言語 | en | |||||
| item_10001_source_id_9 | ||||||
| 収録物識別子タイプ | PISSN | |||||
| 収録物識別子 | 0960-7412 | |||||
| item_10001_relation_14 | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1111/tpj.17203 | |||||
| 情報源 | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://onlinelibrary.wiley.com/doi/10.1111/tpj.17203 | |||||
| 言語 | ja | |||||
| 関連名称 | 出版社サイト | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 言語 | ja | |||||
| 出版タイプ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
